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Diagnostic criteria for multiple myeloma
Monoclonal protein in serum or urine At least 10% Clonal plasma cells in bone marrow or soft tissue/bone plasmacytoma End-organ damage (CRAB) Calcium elevation Renal insufficiency Anemia (usually normocytic) Bone pain (usually due to lytic lesions) Ideally imaging with whole-body low-dose CT scan is better than plain radiograph (skeletal survey)
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