The mitochondria, perhaps better known as the powerhouses of cells, are emerging as a possible factor in the pains of aging.

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

Limonoids, produced during metabolism, are found in high levels in seeds, fruits, and peels of citrus fruits like lemons, limes, and oranges.  Munroni | Cancer ...

A remarkably small bacterium containing fewer than 500 genes serves as the basis for one of the most detailed digital life ...

Researchers have created a method called optovolution that uses light to guide the evolution of proteins with dynamic behaviors. By engineering yeast cells so their survival depended on proteins ...

By simulating the life cycle of a minimal bacterial cell — from DNA replication to protein translation to metabolism and cell division — scientists have opened a new frontier of computer vision into ...

Olvi-Vec shows potential in treating advanced lung cancer, demonstrating tumor shrinkage and disease control in patients unresponsive to platinum-based treatments. The investigational therapy is an ...

This study identifies the uncharacterised protein FAM53C as a novel, potential regulator of the G1/S cell cycle transition, linking its function to the DYRK1A kinase and the RB/p53 pathways. The work ...

XmAb819 demonstrated a manageable safety profile with primarily grade 1 or 2 cytokine release syndrome and no neurotoxicity in ccRCC patients. The trial involved 69 patients, with a 25% objective ...

Benign prostatic hyperplasia (BPH) involves androgen-driven proliferation with reduced apoptosis. Current 5α-reductase inhibitors can cause adverse effects, motivating safer options. We evaluated ...

Background: In adults, injured cardiomyocytes (CMs) rarely regenerate after myocardial infarction (MI), due to limited proliferation and cell cycle activity of CMs, impairing cardiac function.