In the inflamed joints of rheumatoid arthritis, CD4+ T lymphocytes accumulate lipid droplets that make them vulnerable and promote their death, thereby amplifying joint inflammation. A study led by ...

Biomolecules, as physical systems, are distinct molecular entities synthesized or utilized by living organisms that exhibit specific structural, thermodynamic, and dynamical properties enabling ...

Lipids are fatty molecules that play critical roles in cell function, including membrane structure, energy storage and nutrient absorption. Most lipids are made in a cell organelle called the ...

The Xevo CDMS enhances analysis of large biomolecules, crucial for next-gen therapeutics, using individual-particle mass measurement for molecules up to 150+ MDa. Electrostatic Linear Ion Trap (ELIT) ...

A new microfluidic method preserves worm anatomy to link lipid signals with body structure using mass spectrometry imaging. Understanding how fat molecules are distributed and function in living ...

Conventional approaches have relied on techniques like electroporation or chemical treatment, which often damage both the drugs and exosomes, reduce delivery efficiency, and require complex ...

Human metabolism is a complex web of chemical processes and interactions between our cells and the microbes living within us. The more scientists can identify and classify the molecules involved in ...

One particular challenge for biologists is seeing all the molecules in an intact tissue sample, down to the level of single cells, simultaneously. Now US researchers have found a way to expand tissue ...

TEMI mapping of lipid distribution across cerebellar layers. This image shows lipid species specifically enriched in three distinctive layers of the cerebellum: molecular layer, white matter layer and ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

New research has uncovered a surprising culprit underlying cardiovascular diseases in obesity and diabetes -- not the presence of certain fats, but their suppression. The study challenges the ...