The hamartomatous polyposis syndromes are a heterogeneous group of disorders that share an autosomal-dominant pattern of inheritance and are characterized by hamartomatous polyps of the ...

Juvenile polyposis syndrome is a condition transmitted from parents to offspring, which causes the development of juvenile polyps inside the large intestine, stomach, or throughout the ...

Juvenile polyposis syndrome (JPS) refers to a condition in which there are multiple benign polyps in the colon, or large intestine. Polyps are outgrowths occurring on the inside of a hollow organ. The ...

Role of independent data-monitoring committees in randomized clinical trials sponsored by the National Cancer Institute. BTP patients encompass a heterogeneous group that can be classified into two ...

ST316 interfered with β-catenin immune-exclusion allowing for stronger cytotoxic T-cell activity. The Food and Drug Administration (FDA) has granted Orphan Drug designation to ST316 for the treatment ...

Encapsulated rapamycin is expected to prevent disease progression by inhibiting mTOR, a protein kinase that has been shown to be overexpressed in FAP polyps. The Food and Drug Administration (FDA) has ...

Patients with germline pathogenic variants (PVs) in APC develop tens (attenuated familial adenomatous polyposis [AFAP]) to innumerable (classic FAP) adenomatous polyps in their colon and are at ...

Tezepelumab (Tezspire) has shown significant clinical benefits in adults with severe chronic rhinosinusitis with nasal polyps (CRSwNP), including marked reductions in nasal congestion and polyp size ...