While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Gut health has been shown to be central to the body’s overall health, impacting the immune system and the gut-brain axis. The gut barrier plays a key role in maintaining overall gut health, as it ...

Researchers at the University of Gothenburg, Sweden, have uncovered a critical mechanism that may pave the way for innovative treatments for Crohn’s disease. Their findings center on repairing the ...

(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

Organoids with both intestinal and colonic regions are able to better represent the human GI tract with Ebola and Marburg infections.

Ever notice that as you get older, some foods no longer sit with you the same? This could be due to a breakdown of the ...

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively ...

"Understanding how MUC17 is transported within intestinal epithelial cells to ultimately form the protective glycocalyx on the cell surface allows us to identify new drug targets that repair the ...