The thiazolidinediones (glitazones) activate PPAR-gamma, a nuclear receptor implicated in the modulation of adipocyte differentiation and glucose metabolism. These agents reduce glucose levels, ...

There is so far a lack of scientific evidence that glitazones are better than alternative therapies at reducing mortality or complications caused by blood vessel damage in people with type 2 diabetes.

There is so far a lack of scientific evidence that glitazones are better than alternative therapies at reducing mortality or complications caused by blood vessel damage in people with type 2 diabetes.

NOTTINGHAM, UK — In a population-based cohort of patients with type 2 diabetes who were seen in the past decade in clinical practices in the UK, those who received thiazolidinediones (TZDs or ...

There is no convincing evidence that the newer class of diabetes drugs, known as glitazones, offer real advantages over other diabetes drugs, when used on their own, concludes the Drug and ...

The two licensed glitazone antidiabetics, pioglitazone (Actos, Takeda) and rosiglitazone (Avandia, GlaxoSmithKline), now account for more than 50% of expenditure on oral hypoglycaemic drugs in the ...

Diabetic patients who take anti-diabetic drugs - known as glitazones – long term had a lower risk of primary and secondary brain cancer compared with diabetic patients on other medications, new ...

The American Journal of Managed Care provides insights into the latest news and research in managed care across multimedia platforms.

Two observational studies report opposite effects of glitazones on clinical outcomes in patients with ESRD. Given the limited reliability of such studies in the assessment of moderate effects of ...

Diabetic patients who take anti-diabetic drugs - known as glitazones - long term had a lower risk of primary and secondary brain cancer compared with diabetic patients on other medications, new ...

Pioglitazone is not linked to the development of bladder cancer. Pioglitazone was not linked to bladder cancer in an extensive analysis. The thiazolidinedione pioglitazone, which targets insulin ...

There is no convincing evidence that the newer class of diabetes drugs, known as glitazones, offer real advantages over other diabetes drugs, when used on their own, concludes the Drug and ...