Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Medicines come from chemical reactions, and better chemical reactions lead to better medicines. Yet, the most popular reaction used in drug discovery, called the amide coupling, makes an inherently ...

Novel, atom-efficient routes to amides from esters and carboxylic acids for more sustainable manufacturing. It is well known that amide-formation chemistry can be inefficient and warrants further ...

Commercial-scale amide formation and an improved process route for a tetracycline derivative are some recent developments in API synthesis. Process chemists in the fine-chemicals and pharmaceutical ...

The structure fluctuations of the peptide bond interacting with solvent are examined through the coupling and correlations of the frequency distributions of amide I and amide II transitions. The ...

This is a preview. Log in through your library . Abstract Electrostatic (through-space) and covalent (through-bond) contributions to couplings involving the C=O and C-N vibrational stretching modes of ...

If you’re a chemist working with peptide coupling agents, you can literally become allergic to the lab, according to a new report. Over the course of three years, graduate student Kate McKnelly of the ...